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Delaying the Mitochondrial Decay of Aging
Author(s) -
AMES BRUCE N.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.073
Subject(s) - mitochondrion , accelerated aging , degeneration (medical) , brain aging , energy metabolism , ageing , biology , neuroscience , medicine , chemistry , microbiology and biotechnology , pathology , endocrinology , genetics , cognition
A bstract : Mitochondrial dysfunction may be a principal underlying event in aging, including the degenerative diseases of aging such as brain degeneration. Mitochondria provide energy for basic metabolic processes, and their decay with age impairs cellular metabolism and leads to cellular decline. Progress over the last decade in delaying the mitochondrial decay of aging is reviewed.