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Alpha‐Lipoic Acid Increases Na + K + ATPase Activity and Reduces Lipofuscin Accumulation in Discrete Brain Regions of Aged Rats
Author(s) -
ARIVAZHAGAN P,
PANNEERSELVAM C
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.060
Subject(s) - lipofuscin , oxidative stress , endocrinology , lipoic acid , medicine , striatum , hippocampus , chemistry , cerebellum , antioxidant , hypothalamus , alpha lipoic acid , biochemistry , biology , dopamine
A bstract : A convincing link between oxidative stress and neurodegenerative diseases has been found with the knowledge that it actually damages neuronal cells in culture. We analyzed the effect of dl‐α‐lipoic acid on lipofuscin and Na + K + ATPase in discrete brain regions of young and aged rats. In aged rats, the level of lipofuscin was increased, and the activity of Na + K + ATPase was decreased. Intraperitoneal administration of lipoic acid to aged rats led to a duration‐dependent reduction and elevation in lipofuscin and enzyme activity, respectively, in the cortex, cerebellum, striatum, hippocampus, and hypothalamus of the brain. These results suggest that lipoic acid, a natural metabolic antioxidant, should be useful as a therapeutic tool in preventing neuronal dysfunction in aged individuals.