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Lysosomal Redox‐Active Iron Is Important for Oxidative Stress‐Induced DNA Damage
Author(s) -
KURZ TINO,
LEAKE ALAN,
ZGLINICKI THOMAS,
BRUNK ULF T.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.048
Subject(s) - oxidative stress , redox , dna damage , chemistry , dna , dna oxidation , oxidative phosphorylation , oxidative damage , biophysics , nucleus , biochemistry , oxidation reduction , microbiology and biotechnology , biology , inorganic chemistry
A bstract : Data show that specifically chelating lysosomal redox‐active iron can prevent most H 2 O 2 ‐induced DNA damage. Lysosomes seem to contain the major pool of redox‐active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.