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Protective Effects of Mutant Ubiquitin in Transgenic Mice
Author(s) -
GRAY D A,
TSIRIGOTIS M,
BRUN J,
TANG M,
ZHANG M,
BEYERS M,
WOULFE J
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.035
Subject(s) - ubiquitin , mutant , transgene , proteasome , microbiology and biotechnology , genetically modified mouse , in vivo , biology , genetics , gene
A bstract : The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.