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The Aging/Precancerous Gastric Mucosa: A Pilot Nutraceutical Trial
Author(s) -
MAROTTA F,
BARRETO R,
TAJIRI H,
BERTUCCELLI J,
SAFRAN P,
YOSHIDA C,
FESCE E
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.031
Subject(s) - nutraceutical , gastric mucosa , medicine , precancerous condition , gastroenterology , stomach , pathology , cancer
A bstract : The aim of this study was to test the effect of antioxidant supplementation on enzymatic abnormalities and free radical‐modified DNA adducts associated with premalignant changes in the gastric mucosa of elderly patients with HP‐negative atrophic gastritis (CAG). Sixty patients with atrophic gastritis and intestinal metaplasia underwent a nutritional interview and a gastroscopy with multiple biopsy samples in the antrum that were processed for histology and for assaying: alpha‐tocopherol, MDA, xanthine oxidase (XO), ornithine decarboxylase (ODC), and 8‐OHdG. Patients were randomly allocated into three matched groups and supplemented for 6 months with (1) vitamin E, 300 mg/day; (2) multivitamin, two tablets t.i.d.; and (3) Immun‐Age 6 g/day nocte (ORI, Gifu, Japan), a certified fermented papaya preparation with basic science‐validated antioxidant/immunomodulant properties. Ten dyspeptic patients served as controls. Histology and biochemistry were blindly repeated at 3 and 6 months. CAG patients showed a significantly ( P < .05 ) increased level of mucosal MDA and XO concentration that were reverted to normal by each supplementation ( P < .05 ). All supplements caused a significant decrease of ODC ( P < .01 ), but Immun‐Age yielded the most effective ( P < 0.05 ) and was the only one significantly decreasing 8‐OhdG ( P < 0.05 ). These data suggest that antioxidant supplementation, and, namely, Immun‐Age, might be potential chemopreventive agents in HP‐eradicated CAG patients and especially in the elderly population.