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T Cell Replicative Senescence Pleiotropic Effects on Human Aging
Author(s) -
EFFROS RITA B.
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.022
Subject(s) - senescence , cd28 , immune system , biology , microbiology and biotechnology , cd8 , proinflammatory cytokine , effector , t cell , cytotoxic t cell , homeostasis , immunology , inflammation , genetics , in vitro
A bstract : Long‐term culture studies using CD8 T cells, the immune cells responsible for control of viral infection, have identified the major features of replicative senescence. Aging is associated with increased proportions of CD8 T cells with similar characteristics, such as absence of expression of the CD28 costimulatory molecule and reduced antiviral effector functions. Proinflammatory cytokines produced by senescent CD8 T cells also may exert pleiotropic suppressive effects on overall immune function and bone homeostasis. Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age‐associated pathologies.