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Oxidative Stress to Dopaminergic Neurons as Models of Parkinson's Disease
Author(s) -
GILLE G,
HUNG ST,
REICHMANN H,
RAUSCH WD
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1296.066
Subject(s) - rotenone , dopaminergic , tyrosine hydroxylase , oxidative stress , parkinson's disease , dopamine , levodopa , chemistry , bioenergetics , respiratory chain , mitochondrial respiratory chain , oxidative phosphorylation , pharmacology , mitochondrion , biochemistry , neuroscience , biology , medicine , disease
A bstract : The effects of exogenous toxins (MPP + , rotenone) and potentially neurotoxic properties of levodopa (L‐DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP + ‐toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q 10 (CoQ 10 ) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP + is demonstrated.