Premium
Changes in the Concentrations of Tetrahydrobiopterin, the Cofactor of Tyrosine Hydroxylase, in Blood under Physical Stress and in Depression
Author(s) -
HASHIMOTO R,
NAGATSU T,
OHTA T,
MIZUTANI M,
OMURA I
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1296.047
Subject(s) - tetrahydrobiopterin , tyrosine hydroxylase , cofactor , tyrosine , depression (economics) , endocrinology , tyrosine 3 monooxygenase , chemistry , medicine , biochemistry , enzyme , economics , macroeconomics
A bstract : This paper studies changes in the concentrations of tetrahydrobiopterin (BH4), the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression. BH4 was found to be transiently released from the sympathetic nerves under severe physical stress but continuously released in depression with an increased oxidation rate of BH4 to B.