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Glucocorticoid Receptor and Beta‐Adrenoceptor Expression in Epididymal Adipose Tissue from Stressed Rats
Author(s) -
FARIASSILVA ELISÂNGELA,
DOS SANTOS IRAÍDES NUNES,
AMARAL MARIA ESMÉRIA COREZOLA,
GRASSIKASSISSE DORA MARIA,
SPADARIBRATFISCH REGINA CELIA
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1296.040
Subject(s) - endocrinology , medicine , adipose tissue , glucocorticoid receptor , corticosterone , glucocorticoid , receptor , isoprenaline , adrenergic receptor , downregulation and upregulation , chemistry , norepinephrine , heat shock protein , adrenergic , biology , stimulation , gene , hormone , biochemistry , dopamine
A bstract : Adipocytes isolated from epididymal adipose tissue of foot‐shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress‐induced increase in plasma corticosterone levels. We investigated whether foot‐shock stress modifies the expression of glucocorticoid receptors (GRs) and β‐adrenergic protein receptors (β‐ARs) in epididymal adipose tissue from rats submitted to one daily foot‐shock session on three consecutive days. This stress protocol caused decreases in GR, β 1 ‐AR, and β 3 ‐AR protein levels, but caused an increase in β 2 ‐AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.