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Repeated Stress‐Induced Stimulation of Catecholamine Response Is Not Followed by Altered Immune Cell Redistribution
Author(s) -
IMRICH RICHARD,
TIBENSKA ELENA,
KOSKA JURAJ,
KSINANTOVA LUCIA,
KVETNANSKY RICHARD,
BERGENDIOVASEDLACKOVA KATARINA,
BLAZICEK PAVOL,
VIGAS MILAN
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1296.031
Subject(s) - endocrinology , medicine , immune system , cd11a , epinephrine , stimulation , catecholamine , lymphocyte , chemistry , immunology , integrin alpha m , cd18
A bstract : Stress response is considered an important factor in the modulation of immune function. Neuroendocrine hormones, including catecholamines, affect the process of immune cell redistribution, important for cell‐mediated immunity. This longitudinal investigation was aimed at evaluating the effect of repeated stress‐induced elevation of catecholamines on immune cell redistribution and expression of adhesive molecules. We assessed the responses of epinephrine (EPI), norepinephrine (NE), cortisol, changes in lymphocytes subpopulations, and percentages of CD11a+, CD11b+, and CD62L+ lymphocytes to a 20‐min treadmill exercise of an intensity equal to 80% of the individual's Vo 2 max. The exercise was performed before and after 6 weeks of endurance training consisting of a 1‐h run 4 times a week (ET) and after 5 days of bed rest (HDBR) in 10 healthy males. We did not observe any significant changes in the basal levels of EPI, NE, and cortisol in the plasma, nor in the immune parameters after ET and HDBR. The exercise test led to a significant ( P < .001 ) elevation of EPI and NE levels after both ET and HDBR, a significant elevation ( P < .01 ) of cortisol after HDBR, an increase in the absolute numbers of leukocytes, granulocytes, monocytes, CD3+, CD4+, CD8+, CD16+, CD19+ lymphocytes, percentage of CD11a+ and CD11b+ lymphocytes, and to a decrease of CD62L1 before, after ET, and after HDBR. We found comparable changes in all measured immune parameters after ET and HDBR. In conclusion, repeated stress‐induced elevation of EPI and NE was not associated with an alteration in immune cell redistribution found in response to the single bout of exercise.