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Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells
Author(s) -
GÖKE RÜDIGER,
GREGEL CORNELIA,
GÖKE ALEXANDRA,
ARNOLD RUDOLF,
SCHMIDT HARALD,
LANKATBUTTGEREIT BRIGITTE
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1294.024
Subject(s) - suppressor , downregulation and upregulation , programmed cell death , tumor cells , chemistry , tumor suppressor gene , microbiology and biotechnology , cancer research , cell growth , cell , biology , gene , apoptosis , carcinogenesis , biochemistry
A bstract : PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4‐induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.