Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells | Zendy

GÖKE RÜDIGER | Zendy; GREGEL CORNELIA | Zendy; GÖKE ALEXANDRA | Zendy; ARNOLD RUDOLF | Zendy; SCHMIDT HARALD | Zendy; LANKATBUTTGEREIT BRIGITTE | Zendy

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Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells

Author(s) -

GÖKE RÜDIGER,

GREGEL CORNELIA,

GÖKE ALEXANDRA,

ARNOLD RUDOLF,

SCHMIDT HARALD,

LANKATBUTTGEREIT BRIGITTE

Publication year - 2004

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1294.024

Subject(s) - suppressor , downregulation and upregulation , programmed cell death , tumor cells , chemistry , tumor suppressor gene , microbiology and biotechnology , cancer research , cell growth , cell , biology , gene , apoptosis , carcinogenesis , biochemistry

A bstract : PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4‐induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.

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