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Principles of Exocytosis and Membrane Fusion
Author(s) -
JAHN REINHARD
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1294.018
Subject(s) - exocytosis , lipid bilayer fusion , rab , munc 18 , microbiology and biotechnology , vesicle fusion , vesicular transport proteins , chemistry , membrane , biology , vesicle , synaptic vesicle , biochemistry , cytoplasm , gtpase , vacuole , vacuolar protein sorting
A bstract : Exocytosis is a ubiquitous process occurring in every eukaryotic cell including processes as diverse as membrane expansion during growth and the highly regulated release of neurotransmitter from neurons. Work during the past decade has established that exocytotic membrane fusion is mediated by members of conserved protein families including Rab proteins and SNAREs. SNAREs are probably catalyzing membrane fusion, and major progress has been made in unraveling their molecular mechanism. In contrast, less is known about regulatory mechanisms. Here, a brief overview is given about the current state of knowledge, focusing on SNAREs involved in neuronal exocytosis.