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Immunohistochemical Localization of Somatostatin Receptor sst2A in Human Gut and Lung Tissue: Possible Implications for Physiology and Carcinogenesis
Author(s) -
Gugger M,
Waser B,
Kappeler A,
Schonbrunn A,
Reubi JC
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1294.013
Subject(s) - somatostatin , gastrin , jejunum , pathology , somatostatin receptor , ileum , biology , myenteric plexus , immunohistochemistry , anatomy , medicine , neuroscience , endocrinology , secretion
A bstract : Many neuroendocrine gastrointestinal and lung tumors express sst2A somatostatin receptors. Because the cellular location of sst2A in the corresponding non‐neoplastic tissue is unknown, we searched for sst2A immuno‐reactive cells and characterized their type in these tissues using a highly specific sst2A antibody (R2–88). Epithelial sst2A cells, identified as neuroendocrine, gastrin‐producing cells, were found in large numbers in the antrum and the duodenum, but not in the gastric corpus. They were also present in the proximal jejunum, rarely noted in the distal jejunum and ileum, and absent in the large intestine and the appendix vermiformis. Moreover, sst2A cells were found abundantly in the neural plexus. sst2A receptors on antral gastrin cells could mediate somatostatin inhibition on gastrin secretion, whereas those in the neural plexus could mediate somatostatin effects on motility and ion transport in the lower gastrointestinal tract. Rare sst2A cells in bronchi and bronchioles located basally and parabasally in the gastrointestinal epithelium were detected that could represent stem/progenitor cells. It is currently not clear whether and which of the identified sst2A cells are at the origin of sst2A‐positive neuroendocrine gut or lung tumors.

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