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In Vitro Fertilization: Angiogenic, Proliferative, and Apoptotic Factors in the Follicular Fluid
Author(s) -
MALAMITSIPUCHNER ARIADNE,
SARANDAKOU ANGELIKI,
BAKA STAVROULA,
HASIAKOS DEMETRIOS,
KOUSKOUNI EVANGELIA,
CREATSAS GEORGE
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1290.043
Subject(s) - angiogenin , follicular fluid , angiogenesis , basic fibroblast growth factor , oocyte , andrology , vascular endothelial growth factor , apoptosis , follicular phase , growth factor , endocrinology , neovascularization , medicine , chemistry , biology , microbiology and biotechnology , vegf receptors , embryo , receptor , biochemistry
A bstract : The studies reported investigated the concentrations of angiogenic, proliferative, and apoptotic factors in the follicular fluid (FF) of individual follicles, aspirated from women undergoing controlled ovarian hyperstimulation using a long protocol for IVF treatment. Furthermore, the association of the concentrations of the preceding factors with oocyte maturity was studied. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, tissue polypeptide specific antigen (TPS), and soluble Fas (sFas) were all found in the FF of all follicles examined. Moreover, from the angiogenic factors only angiogenin concentrations, and from the apoptotic factors sFas concentrations (the soluble form expressing rather an antiapoptotic function), were positively associated with oocyte maturity, possibly indicating angiogenin's biological role beyond neovascularization and a lower apoptotic rate allowing oocytes to mature. Last, the abundant expression of TPS in FF may be indicative of intense cell proliferation, in cases of ovarian stimulation.