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Population‐wide Infant Screening for HLA‐Based Type 1 Diabetes Risk via Dried Blood Spots from the Public Health Infrastructure
Author(s) -
WION EMILY,
BRANTLEY MICHAEL,
STEVENS JEFF,
GALLINGER SUSAN,
PENG HUI,
GLASS MICHAEL,
HAGOPIAN WILLIAM
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.067
Subject(s) - type 1 diabetes , medicine , diabetes mellitus , population , human leukocyte antigen , public health , dried blood , autoantibody , incidence (geometry) , autoimmunity , environmental health , immunology , pediatrics , disease , endocrinology , antibody , pathology , antigen , optics , physics , chemistry , chromatography
A bstract : The frequency of type 1 diabetes mellitus (T1DM)‐associated HLA DQ alleles in the U.S. Pacific Northwest is as high as in Scandinavia, which has the highest T1DM incidence in the world. The high regional rate of islet autoimmunity observed among DPT‐1 relatives supports this notion. Fortunately, Washington State archives dried blood spots after legislature‐mandated newborn screening. The Diabetes Evaluation in Washington (DEW‐IT) study aims to show that population‐based prospective prediction of T1DM by HLA genotype screening followed by autoantibody surveillance can be performed within the public health infrastructure.