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Two Cases of “Fulminant” Type 1 Diabetes Suggesting Involvement of Autoimmunity
Author(s) -
NAKAGAWA YOSHINORI,
SHIMADA AKIRA,
OIKAWA YOICHI,
IRIE JUNICHIRO,
SHIGIHARA TOSHIKATSU,
TSUMURA KAZUHIRO,
NARUMI SHOSAKU,
SARUTA TAKAO
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.059
Subject(s) - autoimmunity , fulminant , autoantibody , immunology , type 1 diabetes , medicine , islet , diabetes mellitus , immune system , antibody , endocrinology
A bstract : Recently, a novel subtype of type 1 diabetes, so‐called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable “islet‐associated” autoantibody, so it was originally proposed as being “nonautoimmune‐mediated”; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon‐inducible protein‐10 and glutamic acid decarboxylase‐reactive CD4 + interferon‐γ‐producing cells in the peripheral blood are good markers for T cell‐mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet‐associated autoimmunity is suggested.