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Interleukin‐10 Gene Promoter Region Polymorphisms in Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Author(s) -
IDE AKANE,
KAWASAKI EIJI,
ABIRU NORIO,
SUN FUYAN,
FUKUSHIMA TETSUYA,
ISHII REIKO,
TAKAHASHI RYOKO,
KUWAHARA HIRONAGA,
FUJITA NARUHIRO,
KITA ATSUSHI,
IMAIZUMI MISA,
OSHIMA KATSUYA,
USA TOSHIRO,
UOTANI SHIGEO,
EJIMA ERI,
YAMASAKI HIRONORI,
ASHIZAWA KIYOTO,
YAMAGUCHI YOSHIHIKO,
EGUCHI KATSUMI
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.055
Subject(s) - medicine , graves' disease , haplotype , genotype , type 1 diabetes , allele , autoimmune disease , immunology , endocrinology , type 2 diabetes , genetic predisposition , case control study , diabetes mellitus , polymorphism (computer science) , disease , autoimmunity , gene , biology , genetics
A bstract : Type 1 diabetes is a heterogeneous autoimmune disease and is frequently associated with other organ‐specific autoimmune diseases, including autoimmune thyroid disease (AITD). Type 1 diabetic patients with AITD are known to show distinct clinical and immunological features from patients without AITD. This study investigated whether interleukin‐10 (IL‐10) gene promoter region polymorphisms are associated with susceptibility to type 1 diabetes and AITD. The frequency of −1082G/A, −819C/T, and −592C/A polymorphisms was analyzed in 54 type 1 diabetic patients with AITD, 74 type 1 diabetic patients without AITD, 124 nondiabetic patients with AITD, and 107 healthy subjects in a case‐control study. No significant differences on the allele and genotype frequencies of three polymorphisms were found not only in type 1 diabetic patients with AITD compared with normal controls, but also between nondiabetic patients with AITD and healthy controls. The distribution of IL‐10 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that IL‐10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD.