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Caspase 7 Is a Positional Candidate Gene for IDDM 17 in a Bedouin Arab Family
Author(s) -
BABU SUNANDA R.,
BAO FEI,
ROBERTS CHRISTINE M.,
MARTIN ALLISON K.,
GOWAN KATHERINE,
EISENBARTH GEORGE S.,
FAIN PAMELA R.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.054
Subject(s) - gene , genetics , biology
A bstract : The IDDM 17 locus was mapped to an 8‐cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7 (CASP7), an apoptosis‐related cysteine protease, is one of the few known genes in this region. CASP7 is involved in the activation cascade of caspases responsible for apoptosis execution. Only 1 of the 18 SNPs in CASP7 (SNP144692) differed significantly in frequency in the haplotypes found in affected individuals compared to control Bedouin haplotypes. This same SNP showed evidence of association with diabetes in a subset of patients (DR3/DR4*0302) from HBDI families.