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MIC‐A Genotypes 4/5.1 and 9/9 Are Positively Associated with Type 1 Diabetes Mellitus in Brazilian Population
Author(s) -
TICA VALERIA,
NIKITINAZAKE LIENE,
DONADI EDUARDO,
SANJEEVI CARANI B.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.048
Subject(s) - genotype , medicine , diabetes mellitus , type 1 diabetes , allele , gastroenterology , population , biology , genetics , gene , endocrinology , environmental health
A bstract : The aim of our study was to evaluate the frequencies of MIC‐A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain‐related gene‐A (MIC‐A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC‐A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC‐A 4/5.1 ( pc = 0.006; OR, 6.1) and 9/9 ( pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).