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IL‐6 Modulates Hyperglycemia‐Induced Changes of Na+ Channel Beta‐3 Subunit Expression by Schwann Cells
Author(s) -
SKUNDRIC DUSANKA S.,
DAI RUJUAN,
MATAVERDE PHILIP
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.034
Subject(s) - protein subunit , diabetic neuropathy , beta (programming language) , g alpha subunit , endocrinology , chemistry , medicine , expression (computer science) , neuroscience , pharmacology , biology , diabetes mellitus , biochemistry , gene , computer science , programming language
A bstract : Our data show the suppressive effect of hyperglycemia on expression of voltage‐gated Na+ channel β3 subunit by Schwann cells as well as the protection of β3 expression by treatment with IL‐6. Our findings have direct relevance for therapy of diabetic neuropathy.