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NKT Cell Frequency in Japanese Type 1 Diabetes
Author(s) -
OIKAWA YOICHI,
SHIMADA AKIRA,
YAMADA SATORU,
MOTOHASHI YOSHIKO,
NAKAGAWA YOSHINORI,
IRIE JUNICHIRO,
MARUYAMA TARO,
SARUTA TAKAO
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.033
Subject(s) - natural killer t cell , type 1 diabetes , pathogenesis , cell , diabetes mellitus , immunology , type 2 diabetes , islet , disease , cell type , medicine , biology , endocrinology , t cell , immune system , biochemistry
A bstract : A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet‐associated Ab+ and Ab− Japanese “classic” type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab−“classic” type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.