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Characterization of Dendritic Cells in Humans with Type 1 Diabetes
Author(s) -
SUMMERS KELLY L.,
BEHME MARGARET T.,
MAHON JEFFERY L.,
SINGH BHAGIRATH
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.032
Subject(s) - diabetes mellitus , phenotype , pancreatic islets , pathological , type 2 diabetes , type 1 diabetes , medicine , immunology , in vivo , dendritic cell , islet , endocrinology , biology , antigen , gene , genetics
A bstract : The characterization of dendritic cells (DCs) in diabetes has primarily examined in vitro ‐generated DCs. In this study, we have compared the composition and phenotype of naturally occurring DCs within the peripheral blood of subjects with type 1 diabetes, latent‐onset autoimmune diabetes in adults, and nondiabetic controls. We find that circulatory DC subsets exist in normal frequencies and phenotypic states in diabetic patients. In vivo , DCs were located around the pancreatic islets in type 1 diabetic patients, but were absent in pancreatic tissue of normal controls. These findings provide new insight toward understanding the pathological role of DCs in type 1 diabetes.