Defective Activation‐Induced Cell Death in NOD T Lymphocytes | Zendy

DECALLONNE B. | Zendy; MATHIEU C. | Zendy

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Defective Activation‐Induced Cell Death in NOD T Lymphocytes

Author(s) -

DECALLONNE B.,

MATHIEU C.

Publication year - 2003

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1288.021

Subject(s) - insulitis , nod , nod mice , apoptosis , programmed cell death , effector , immunology , in vivo , in vitro , biology , biochemistry , microbiology and biotechnology

A bstract : The aim of this study was first to analyze strain differences in apoptosis resistance of NOD peripheral T lymphocytes in in vitro models of death by neglect and activation‐induced cell death (AICD). Especially AICD is known to play a key role in peripheral tolerance, keeping autoimmune effector cells under control. Second, we studied the effects of in vivo treatment of NOD mice with 1α,25‐dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ], an immunomodulator known to prevent diabetes and insulitis in NOD mice, on in vitro T lymphocyte apoptosis resistance.

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