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Oxidative Stress in Type 1 Diabetes
Author(s) -
HASKINS KATHRYN,
BRADLEY BRENDA,
POWERS KATHERINE,
FADOK VALERIE,
FLORES SONIA,
LING XIAOFENG,
PUGAZHENTHI SUBBIAH,
REUSCH JANE,
KENCH JENNIFER
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1288.006
Subject(s) - oxidative stress , nod , nod mice , superoxide dismutase , pathogenesis , diabetes mellitus , cytokine , endocrinology , type 1 diabetes , medicine , macrophage , immunology , chemistry , biochemistry , in vitro
A bstract : We have been investigating the effects of preventing oxidative stress on pathogenesis and complications of type 1 diabetes in the NOD mouse model. Our studies have shown that damage caused by oxidative stress is higher in islets and vascular tissue of NOD mice than in nonautoimmune controls or a diabetes‐resistant NOD mouse. In addition, phagocytic function and cytokine production by macrophages are aberrant in the NOD. We have demonstrated that treatment of prediabetic NOD mice for 2 weeks with a metalloporphyrin superoxide dismutase (SOD) mimetic results in marked reduction of oxidative stress in islets and vascular tissue and a reversal of macrophage defects.