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Neurogenesis in the Subependymal Layer of the Adult Rat
Author(s) -
GIACHINO CLAUDIO,
GALBIATI MARIARITA,
FASOLO ALDO,
PERETTO PAOLO,
MELCANGI ROBERTO
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1286.032
Subject(s) - subependymal zone , olfactory bulb , neurogenesis , microbiology and biotechnology , central nervous system , chemistry , neuroglia , neuroscience , hippocampal formation , biology
A bstract : The subependymal layer (SEL) of the adult mammalian brain provides a continuous supply of newborn cells that migrate to the olfactory bulb (OB) where they differentiate into interneurons. These newly generated cells migrate tangentially to the OB within a dense meshwork of astrocytic cells, organized to form tangentially oriented channels (glial tubes). The central nervous system is able to synthesize a variety of steroids. Among these, we analyzed the effects of progesterone (P) and its neuroactive metabolites dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), administered by intraventricular injection, on the SEL of the adult rat. We found that THP and DHP, but not their precursor P, modify glial tubes organization and decrease immunoreactivity for glial associated proteins in SEL astrocytes. Moreover P metabolites reduce the proliferative activity within the SEL.