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Neurosteroids in the Retina
Author(s) -
GUARNERI P,
CASCIO C,
RUSSO D,
D'AGOSTINO S,
DRAGO G,
GALIZZI G,
LEO G,
PICCOLI F,
GUARNERI M,
GUARNERI R
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1286.012
Subject(s) - neuroactive steroid , neuroprotection , neuroscience , retina , long term potentiation , retinal degeneration , hormone , biology , medicine , endocrinology , receptor , gabaa receptor
A bstract : Steroids may have a powerful role in neuronal degeneration. Recent research has revealed that steroids may influence the onset and progression of some retinal disorders as well as neurodegenerative diseases and, as in brain, they accumulate in the retina via a local synthesis (neurosteroids) and metabolism of blood‐circulating steroid hormones. Their crucial role as neurodegenerative and neuroprotective agents has been also upheld in a retinal excitotoxic paradigm. These findings are reviewed especially from the emerging perspective that after an insult local changes in steroidogenic responses and consequent neurosteroid availability might turn out to be offensive or defensive cellular adaptations for the potentiation or prevention of neuronal death.