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Coevolution of the Relaxin‐Like Peptides and Their Receptors
Author(s) -
WILKINSON TRACEY N.,
SPEED TERENCE P.,
TREGEAR GEOFFREY W.,
BATHGATE ROSS A.D.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.080
Subject(s) - relaxin , coevolution , receptor , evolutionary biology , chemistry , biology , computational biology , biochemistry
A bstract : Currently, four relaxin peptide family receptors are known: LGR7 is the relaxin receptor, although it also interacts specifically with relaxin‐3; LGR8 is the insulin‐like factor 3 (INSL3) receptor; and GPCR135 or the somatostatin‐ and angiotensin‐like peptide receptor (SALPR) and GPCR142 are both specific relaxin‐3 receptors. Because these receptors coevolved together with their relaxin ligands, phylogenetic analysis of these sequences can provide insight into peptide‐receptor interactions and even predict interacting partners for INSL4, INSL5, and INSL6, the receptors for which are unknown.