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Human Recombinant Relaxin Reduces Heart Injury and Improves Ventricular Performance in a Swine Model of Acute Myocardial Infarction
Author(s) -
PERNA AVIOMARIA,
MASINI EMANUELA,
NISTRI SILVIA,
BANI SACCHI TATIANA,
BIGAZZI MARIO,
BANI DANIELE
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.064
Subject(s) - medicine , myocardial infarction , relaxin , cardiology , infarction , adjunctive treatment , ischemia , hormone
A bstract : This study shows that relaxin can be effective in the treatment of acute myocardial infarction. In a swine model of heart ischemia‐reperfusion currently used to test cardiotropic drugs because of its similarities with human myocardial infarction, human recombinant relaxin (2.5 and 5 μg/kg body weight), given at reperfusion after a 30‐min ischemia, markedly reduced the main serum markers of myocardial damage (myoglobin, CK‐MB, and troponin T) and the metabolic and histopathologic parameters of myocardial inflammation and cardiomyocyte injury, resulting in overall improvement of ventricular performance (increased cardiac index) compared to the controls. These results provide a background for future clinical trials with human relaxin as adjunctive therapy to catheter‐based coronary angioplasty in patients with acute myocardial infarction.