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The Use of Relaxin Improves Healing in Injured Muscle
Author(s) -
LI Y,
NEGISHI S,
SAKAMOTO M,
USAS A,
HUARD J
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.060
Subject(s) - relaxin , regeneration (biology) , skeletal muscle , medicine , fibrosis , growth factor , cytokine , insulin like growth factor , sarcopenia , endocrinology , biology , hormone , microbiology and biotechnology , receptor
A bstract : To improve the functional recovery of injured skeletal muscle, we have focused our efforts on both enhancement of muscle regeneration and prevention of fibrosis. The polypeptide cytokine/growth factor relaxin can inhibit fibrous tissue formation in many tissues. As a member of the insulin‐like growth factor family, relaxin also is a potential stimulator of muscle regeneration. In the current experiment, we examined the antifibrotic effect of relaxin in injured skeletal muscle. We also investigated if the injection of relaxin would influence muscle regeneration after injury. Our results demonstrate that relaxin treatment improved histologic and physiologic healing of muscles subjected to traumatic injury.