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Relaxin Regulates Collagen Overproduction Associated with Experimental Progressive Renal Fibrosis
Author(s) -
SAMUEL CHRISHAN S.,
MOOKERJEE ISHANEE,
MASTERSON ROSEMARY,
TREGEAR GEOFFREY W.,
HEWITSON TIM D.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.026
Subject(s) - relaxin , fibrosis , extracellular matrix , overproduction , endocrinology , medicine , disease , hormone , chemistry , biochemistry , enzyme
A bstract : Progressive fibrosis due to excess extracellular matrix (primarily collagen) is the final common pathway in all forms of chronic renal disease, regardless of etiology, and leads to tissue dysfunction, when normal tissue is replaced by scar tissue. Emerging work from ourselves and others suggests that the naturally occurring hormone relaxin has the potential to limit renal collagen production and reorganization, while increasing its degradation. The outlined studies demonstrate relaxin's potential as an antifibrotic agent against experimental progressive renal disease.