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Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle
Author(s) -
BOND COURTNEY P.,
PARRY LAURA J.,
SAMUEL CHRISHAN S.,
GEHRING HELEN M.,
LEDERMAN FIONA L.,
ROGERS PETER A. W.,
SUMMERS ROGER J.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.020
Subject(s) - relaxin , endometrium , menstrual cycle , endocrinology , medicine , ovulation , follicular phase , myometrium , biology , receptor , uterus , chemistry , hormone
A bstract : This study investigated localization and expression of relaxin and its receptor, LGR7, in the human endometrium during the proliferative and secretory phases of the menstrual cycle. H2 relaxin binding was identified in endometrium, but not myometrium, and particularly in the epithelium of the endometrial glands and uterine lumen. Binding sites increased in the early secretory phase of the menstrual cycle and were paralleled by similar increases in LGR7 mRNA measured by Q‐PCR. The increase in LGR7 expression and H2 relaxin binding in the secretory phase of the menstrual cycle suggests a specific role for relaxin after ovulation in the human uterus.