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Characterization of the Mouse and Rat Relaxin Receptors
Author(s) -
SCOTT D J,
LAYFIELD S,
RIESEWIJK A,
MORITA H,
TREGEAR G W,
BATHGATE R A D
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1282.002
Subject(s) - relaxin , receptor , biology , microbiology and biotechnology , g protein coupled receptor , gene , reporter gene , biochemistry , gene expression
A bstract : Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine‐rich repeat‐containing g‐protein‐coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterization of the response of LGR7 to relaxin in these species. Partial LGR7 homologous sequences from mouse and rat were discovered in the Celera and NCBI gene databases, amplified, cloned, and sequenced. At the protein level, mouse and rat LGR7 are 85.2% and 85.7% identical to human LGR7. Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands.