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Analysis of CD4 + CD25 + Cell Population in the Thymus from Myasthenia Gravis Patients
Author(s) -
BALANDINA A.,
SAOUDI A.,
DARTEVELLE P.,
BERRIHAKNIN S.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1254.030
Subject(s) - myasthenia gravis , il 2 receptor , immunology , population , phenotype , t cell , biology , microbiology and biotechnology , medicine , immune system , genetics , gene , environmental health
A bstract : The present study is aimed at exploring the regulatory CD4 + CD25 + T cells in the thymus from myasthenia gravis (MG) patients. In early‐onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4 + CD25 + cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.