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Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells
Author(s) -
Kitaichi Nobuyoshi,
Kotake Satoshi,
Morohashi Taiki,
Onoé Kazunori,
Ohno Shigeaki,
Taylor Andrew W.
Publication year - 2002
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.72.6.1117
Subject(s) - antibody , immunology , biology , autoimmune disease
To evaluate the potential role of NK1.1 (CD161c) cells in autoimmune uveoretinitis, we treated experimental autoimmune uveoretinitis (EAU)‐susceptible mice with anti‐CD161c antibodies (PK136) to deplete natural killer (NK) cells. Injection of anti‐CD161c antibodies deleted NK cells from the peripheral blood of EAU‐susceptible mice. The T cell proliferative response against the ocular autoantigen K2 was not suppressed in mice treated with anti‐CD161c antibody when compared with T cells from control mice. Although mice treated with anti‐CD161c developed EAU, the clinical severity on days 17 and 19 after induction of EAU was significantly mild in anti‐CD161c‐treated mice compared with control mice. In addition, the histopathological severity of EAU was significantly milder in mice treated with anti‐CD161c antibodies than controls 21 days after induction of EAU. Our results indicate that the severity of EAU is augmented by NK1.1 + NK cells.