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Orphan nuclear receptors in T lymphocyte development
Author(s) -
He YouWen
Publication year - 2002
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.72.3.440
Subject(s) - biology , neuron derived orphan receptor 1 , nuclear receptor , thymocyte , nerve growth factor ib , haematopoiesis , lymphocyte , receptor , transcription factor , microbiology and biotechnology , immunology , orphan receptor , t cell receptor , stem cell , t cell , immune system , genetics , gene
Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development. The orphan nuclear receptor RORγ has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl‐x L . RORγ is also required for the development of lymph nodes and Peyer's patches. The orphan receptors Nur77 and Nor1 are involved in TCR‐mediated cell death and thymocyte‐negative selection. These studies provide novel insights into the molecular mechanisms of T lymphocyte development.