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Complement’s participation in acquired immunity
Author(s) -
Nielsen Claus Henrik,
Leslie Robert Graham Quinton
Publication year - 2002
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.72.2.249
Subject(s) - biology , complement receptor , immunology , ic3b , complement system , b cell receptor , antigen , context (archaeology) , b cell , antibody , microbiology and biotechnology , alternative complement pathway , receptor , repertoire , genetics , physics , acoustics , paleontology
The preliminary evidence for the involvement of complement in promoting primary humoral responses dates back over a quarter of a century. However, it is only in the course of the past decade or so that the detailed mechanisms underlying complement’s influence have been characterized in depth. It is now clear that complement serves as a regulator of several B cell functions, including specific antibody production, antigen uptake, processing and presentation, and shaping of the B cell repertoire. Of key importance, in this respect, is the role played by the B cell‐signaling triad consisting of the B cell receptor for antigen (BCR), a complex composed of the iC3b/C3d fragment‐binding complement type 2 receptor (CR2, CD21) and its signaling element CD19 and the IgG‐binding receptor FcγRIIb (CD32). The positive or negative outcome of signaling through this triad is determined by the context in which antigen is seen, be it alone or in association with natural or induced antibodies and/or C3‐complement fragments. The aim of this review is to describe the present status of our understanding of complement’s participation in acquired immunity and the regulation of autoimmune responses.