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Mechanisms of TNF receptor‐associated factor (TRAF) regulation in B lymphocytes
Author(s) -
Bishop Gail A.,
Hostager Bruce S.,
Brown Kevin D.
Publication year - 2002
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.72.1.19
Subject(s) - biology , microbiology and biotechnology , receptor , signal transduction , signal transducing adaptor protein , tumor necrosis factor alpha , cytoplasm , immunology , genetics
A key component of signaling by members of the tumor necrosis factor receptor (TNF‐R) family is interaction with the cytoplasmic adapter proteins known as TRAFs. Several proteins encoded by microbes also interact with TRAFs. A notable example is the CD40 receptor, expressed on antigen presenting cells and providing key activation signals in T cell‐dependent B cell activation. CD40 signals to B cells are mimicked by a constitutively active viral protein produced by the Epstein‐Barr virus. For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview.