Premium
Eicosapentaenoic acid inhibits CSF‐induced human monocyte survival and maturation into macrophage through the stimulation of H 2 O 2 production
Author(s) -
Terada Sachiyo,
Takizawa Mari,
Yamamoto Shigeru,
Ezaki Osamu,
Itakura Hiroshige,
Akagawa Kiyoko S.
Publication year - 2002
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.71.6.981
Subject(s) - monocyte , macrophage , eicosapentaenoic acid , apoptosis , biology , stimulation , macrophage colony stimulating factor , immunology , endocrinology , medicine , biochemistry , in vitro , fatty acid , polyunsaturated fatty acid
Human studies suggest a beneficial effect of eicosapentaenoic acid (EPA)‐supplemented diets on atherosclerotic and atherothrombotic disorders as well as autoimmune and inflammatory diseases and tumors. The effects of EPA on human monocyte survival and maturation into macrophage are not yet known. We studied the effects of EPA on the survival and development into macrophage of human monocyte treated with colony‐stimulating factor (CSF). We have found that EPA induces cell death of the monocyte via apoptosis, even in the presence of M‐CSF or GM‐CSF, and inhibits differentiation from the monocyte to macrophage by inducing H 2 O 2 production. In contrast to the effect of EPA on monocytes, EPA did not induce cell death of monocyte‐derived macrophages. Such an apoptosis inducing effect on monocytes by EPA may contribute to the efficacy of EPA in atherosclerosis and autoimmune diseases.