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Increased CCR4 expression in active systemic lupus erythematosus
Author(s) -
Hase Kayoko,
Tani Kenji,
Shimizu Teruki,
Ohmoto Yasukazu,
Matsushima Kouji,
Sone Saburo
Publication year - 2001
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.70.5.749
Subject(s) - ccr4 , immunology , lupus erythematosus , immune system , monoclonal antibody , antibody , chemokine , autoimmune disease , medicine , biology , chemokine receptor
CC chemokine receptor (CCR)4 is selectively expressed on Th2‐type Tcells and has been shown to be responsible for Th2‐dominant immuneresponses. In this study, we analyzed the expression of CCR4 in activesystemic lupus erythematosus (SLE) patients by FACS analysis usinganti‐human CCR4 monoclonal antibody and determined the clinicalrelevance in this disease. Higher expression of CCR4 was found onperipheral blood CD4+ T lymphocytes of active SLE patients than wasfound with healthy controls and inactive SLE patients. The CCR4expression significantly correlated with the SLE disease activity index(SLEDAI) scores. The expression was dramatically decreased after thecorticosteroid therapy in parallel with a serum level ofdouble‐stranded DNA antibody and SLEDAI scores. Moreover, we found thatserum levels of IL‐10 were increased in active SLE patients andsignificantly correlated with the CCR4 expression. This study suggeststhat Th2 immune response is predominant in the active state of SLE, andCCR4 may have relevance in regard to the disease course in SLEpatients.