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Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies
Author(s) -
Wang Binghe,
Feliciani Claudio,
Freed Irwin,
Cai Qinchao,
Sauder Daniel N.
Publication year - 2001
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.70.2.185
Subject(s) - biology , knockout mouse , gene knockout , gene , hapten , immune system , microbiology and biotechnology , immunology , genetics , antigen
Contact hypersensitivity (CHS), a dendritic‐cell (DC)‐dependent, T‐cell‐mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not fully understood. During the past few years, varieties of gene‐targeted knockout mice have been used in the study of CHS. Such studies have contributed significantly to our understanding of the mechanisms responsible for the initiation of CHS. This review focuses on insights into molecular requirements for CHS gained from knockout studies.