Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies | Zendy

Wang Binghe | Zendy; Feliciani Claudio | Zendy; Freed Irwin | Zendy; Cai Qinchao | Zendy; Sauder Daniel N. | Zendy

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Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies

Author(s) -

Wang Binghe,

Feliciani Claudio,

Freed Irwin,

Cai Qinchao,

Sauder Daniel N.

Publication year - 2001

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.70.2.185

Subject(s) - biology , knockout mouse , gene , gene knockout , computational biology , genetics

Contact hypersensitivity (CHS), a dendritic‐cell (DC)‐dependent, T‐cell‐mediated skin immune response to reactive haptens, has been a subject of intense research for many years. The molecular mechanisms underlying CHS are complicated and are not fully understood. During the past few years, varieties of gene‐targeted knockout mice have been used in the study of CHS. Such studies have contributed significantly to our understanding of the mechanisms responsible for the initiation of CHS. This review focuses on insights into molecular requirements for CHS gained from knockout studies.

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