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Molecular motors involved in T cell receptor clusterings
Author(s) -
Krawczyk Connie,
Penninger Josef M.
Publication year - 2001
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.69.3.317
Subject(s) - biology , immunological synapse , receptor , microbiology and biotechnology , cytoskeleton , t cell receptor , gtpase , antigen , molecular motor , immune system , t cell , cell , immunology , biochemistry
Engagement of antigen receptors on T and B cells triggers reorganization of the cytoskeleton and ordered clustering of cell surface receptors. These receptor clusters constitute spatially organized signaling machines and form the immune synapse with antigen‐presenting cells. Formation of supramolecular activation clusters appear to be essential to induce functional lymphocyte responses and have been implicated as molecular mechanisms of costimulation. The Vav1‐Rho‐GTPase‐WASP pathway constitutes a molecular motor that relays antigen receptor stimulation to changes in the cytoskeleton and receptor clustering.