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Activated human platelets express Fas‐L and induce apoptosis in Fas‐positive tumor cells
Author(s) -
Ahmad Rasheed,
Menezes José,
Knafo Laurent,
Ahmad Ali
Publication year - 2001
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.69.1.123
Subject(s) - apoptosis , platelet , biology , fas ligand , hemostasis , immune system , microbiology and biotechnology , platelet activation , immunology , cancer research , programmed cell death , biochemistry , medicine
In addition to their role in hemostasis and thrombosis, platelets are important modulators of immune and inflammatory responses. We provide evidence here that human platelets contain abundant quantities of Fas‐L, and upon activation, they express it on their surface as well as release it into medium. This surface‐expressed Fas‐L is biologically active and can induce apoptosis in Fas‐positive human tumor cells. Therefore, activated platelets may represent an important player in Fas/Fas‐L‐mediated apoptosis.