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Regulation of chemokine/cytokine network during in vitro differentiation and HIV‐1 infection of human monocytes: possible importance in the pathogenesis of AIDS
Author(s) -
Fantuzzi Laura,
Conti Lucia,
Gauzzi Maria Cristina,
Eid Pierre,
Del Cornò Manuela,
Varano Barbara,
Canini Irene,
Belardelli Filippo,
Gessani Sandra
Publication year - 2000
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.68.3.391
Subject(s) - biology , chemokine , immunology , pathogenesis , cytokine , macrophage , monocyte , macrophage colony stimulating factor , inflammation , in vitro , genetics
The monocyte/macrophage lineage represents heterogeneous cell populations characterized by major differences in the phenotype and functional activities. These cells are a major source of soluble factors, such as cytokines and chemokines, which can both affect HIV replication and AIDS pathogenesis. Although monocytes/macrophages are unanimously considered important targets of HIV‐1 infection, the HIV‐induced alterations in their physiological functions at different stages of differentiation are still matter of debate. In this article, we review our data on the regulation of chemokine/cytokine network with regard to macrophage differentiation and HIV‐1 infection, in comparison with studies from other groups. The ensemble of the results emphasizes that: 1) macrophages markedly differ with respect to monocytes for a variety of responses potentially important in the pathogenesis of HIV infection; and 2) the experimental conditions can influence the HIV‐monocyte/macrophage interactions, reflecting the possible in vivo existence of a spectrum of responses among macrophage populations.