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HIV‐1 genotypes in peripheral blood monocytes
Author(s) -
Zhu Tuofu
Publication year - 2000
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.68.3.338
Subject(s) - biology , cd14 , genotype , immunology , in vivo , human immunodeficiency virus (hiv) , pathogenesis , monocyte , virology , ex vivo , phenotype , virus , macrophage , in vitro , gene , immune system , genetics
CD4 + T cells and tissue macrophages are well defined as the major targets for human immunodeficiency virus type 1 (HIV‐1) infection and replication, and their infection accounts for many aspects of HIV‐1 pathogenesis in vivo. HIV‐1 genotype and phenotype in monocytes and their potential roles in pathogenicity in vivo remain unknown. Herein is an overview of our initial work on HIV‐1 genotype in purified CD14 + monocytes isolated longitudinally during the course of infection starting from the time of infection. Our data provide evidence for HIV‐1 evolution in monocytes and their role as a reservoir of HIV‐1 in vivo. A better understanding of HIV‐1 in monocytes may greatly help the development of new therapeutic strategies for HIV‐1 infection.