Premium
Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis
Author(s) -
Sala Andrea,
Corinti Silvia,
Federici Monica,
Saragovi H. Uri,
Girolomoni Giampiero
Publication year - 2000
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.68.1.104
Subject(s) - nerve growth factor , biology , apoptosis , microbiology and biotechnology , tropomyosin receptor kinase a , receptor , ligand (biochemistry) , low affinity nerve growth factor receptor , cancer research , biochemistry
Nerve growth factor (NGF) receptors are expressed in different cell types outside the nervous system, and increasing evidence indicates that NGF can act as a regulatory molecule during inflammatory and immune responses. In this study, we show that triggering of the high‐affinity NGF receptor TrkA with agonists protects monocytes from apoptosis induced by gliotoxin or UVB radiation. TrkA stimulation up‐regulates the expression of the anti‐apoptotic Bcl‐2 family members, Bcl‐2, Bcl‐X L , and Bfl‐1. On the other hand, TrkA stimulation does not change the expression of MHC, CD80, CD86, CD40, and CD54 molecules, nor the antigen‐presenting function of monocytes. In addition, during in vitro monocyte to dendritic cell differentiation TrkA expression is progressively lost, suggesting that NGF selectively affects monocyte but not dendritic cell survival.