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Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin‐specific T cell autoreactivity
Author(s) -
Ortega Sterling B.,
Kong Xiagmei,
Venkataraman Ramgopal,
Savedra Allen Michael,
Kernie Steven G.,
Stowe Ann M.,
Raman Lakshmi
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5hi0914-447r
Subject(s) - myelinogenesis , myelin , biology , neurogenesis , neuroinflammation , oligodendrocyte , autoimmunity , progenitor cell , immunology , inflammation , t cell , myelin basic protein , neuroscience , microbiology and biotechnology , stem cell , central nervous system , immune system
Chronic hypoxia leads to a loss of myelin in the developing perinatal brain, and an adaptive immune response to myelin in the periphery.