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Frontline Science: Functionally impaired geriatric CAR‐T cells rescued by increased α5β1 integrin expression
Author(s) -
Guha Prajna,
Cunetta Marissa,
Somasundar Ponnandai,
Espat N. Joseph,
Junghans Richard P.,
Katz Steven C.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5hi0716-322rr
Subject(s) - biology , cytotoxic t cell , chimeric antigen receptor , perforin , granzyme b , cd8 , integrin , microbiology and biotechnology , t cell , antigen , interleukin 21 , cancer research , immune system , immunology , receptor , biochemistry , in vitro
Reversal of age‐related CAR‐T dysfunction with M‐CSF or TGF‐β1 treatments can be implemented to bioengineer highly efficacious CAR‐T cells in aged cancer patients.