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Expression and targeting of lymphocyte function‐associated antigen 1 (LFA‐1) on white blood cells for treatment of allergic asthma
Author(s) -
Gupta Anukriti,
Espinosa Vanessa,
Galusha Lindsey E.,
Rahimian Vahid,
Miro Katie L.,
RiveraMedina Amariliz,
Kasinathan Chinnaswamy,
Capitle Eugenio,
Aguila Helen A.,
Kachlany Scott C.
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5hi0414-196r
Subject(s) - immunology , asthma , proinflammatory cytokine , peripheral blood mononuclear cell , population , lymphocyte function associated antigen 1 , house dust mite , medicine , cd11a , inflammation , lung , allergy , biology , immune system , allergen , in vitro , intercellular adhesion molecule 1 , biochemistry , environmental health , integrin alpha m , cd18
LFA‐1 expression defines a unique WBC population in patients with allergic asthma, whereas depleting WBCs expressing active LFA‐1 causes resolution in an experimental mouse model.