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Frontline Science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shock
Author(s) -
Grégoire Murielle,
Tadié JeanMarc,
Uhel Fabrice,
Gacouin Arnaud,
Piau Caroline,
Bone Nathaniel,
Le Tulzo Yves,
Abraham Edward,
Tarte Karin,
Zmijewski Jaroslaw W.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5hi0316-128rr
Subject(s) - hmgb1 , sepsis , septic shock , immunosuppression , nadph oxidase , immunology , biology , proinflammatory cytokine , inflammation , immune system , oxidative stress , endocrinology
HMGB1 in the late phase of sepsis plays a specific role in the development of post‐sepsis immunosuppression, and specifically neutrophil dependent antibacterial defense mechanisms.