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The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function
Author(s) -
Conroy Melissa J.,
Fitzgerald Vivienne,
Doyle Suzanne L.,
Chan Shauna,
Useckaite Zivile,
Gilmartin Niamh,
O'Farrelly Cliona,
Ravi Narayanasamy,
Reynolds John V.,
Lysaght Joanne
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5ab1115-493rr
Subject(s) - biology , adipose tissue , chemokine , tumor necrosis factor alpha , natural killer cell , chemotaxis , cytokine , immunology , inflammation , cell , receptor , medicine , cancer research , endocrinology , cytotoxicity , in vitro , biochemistry , genetics
Soluble factors from VAT and liver can reduce NK cell viability and function, with implications for chronic conditions such as obesity and cancer.